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Description
Based upon these observations, a two-wave model of reactive astrogliosis in the AD continuum was suggested 359,360

Importantly, of all the metabolites that significantly distinguished +ADT from ADT group, the only metabolite that significantly correlated with PROMIS-SRI sleep impairment T -scores was androsterone sulfate, which is a metabolic endpoint marker of the effectiveness of ADT in reducing circulating androgens ( via alterations in the androgenic action on SCN circuitry and circadian rhythmicity
9-15 desoxo-9-x-acetoxy-3,8,12-tri- O -acety-lingol

PLoS ONE 11:e0163216
