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These findings are in line with results obtained by other researchers in two pilot clinical trials, which revealed that topical administration of the TRPM8 agonist (cryosim-3) significantly increased basal tear production and lessened neuropathic pain in DED patients, indicating that the use of TRPM8 agonists could be considered as a potential new therapeutic approach for the treatment of DED-related ocular discomfort [29,30]
With regard to dementia (senile dementia), ALC was shown to be more affective than piracetam (Sinforiani 1990)
& Colagiuri, S
