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These findings suggest that high baseline autophagic activity, particularly when coupled with elevated checkpoint expression, could serve as a biomarker for identifying patients who may benefit from combining autophagy inhibitors with immunotherapy, a hypothesis awaiting robust clinical validation

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In the same study, it was also found that GRP78 can directly control VEGF 165-induced angiogenesis (57)

TPO becomes active only after binding heme molecules, so its activity depends strictly on the iron status of the individual