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Chem Res Toxicol 13:363372

Xia et al., 2014b)

2 The pathophysiology of Parkinsons disease Parkinsons disease, first described by James Parkinson in 1817, is a complex, age-related, progressive, and multisystem neurodegenerative condition associated with dopaminergic neuronal loss and formation of -synuclein (-Syn) protein aggregation in neurons of the substantia nigra (SN) (Morris et al., 2024)

Since these findings proposed an interrelationship between oxidative stress and GN-induced ARF, we investigated this hypothesis in our study revealing that oxidative stress was linked to the induction of ARF in rats using GN, as evidenced by elevated renal MDA levels and decreased levels of nitrite and SOD