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For example, a long-term follow-up of 410 Thai women with melasma treated with dermabrasion evidenced a 95% sustained effect for 5 years and a low rate of adverse effects

In vitro studies indicate that exposure to PS-MPs triggers NF-B pathway activation in microglia, resulting in an overproduction of IL-1, TNF-, and nitric oxide (NO) 37

It can happen in a single generation, and presumably that is exactly what has happened many, many times in the deep past
doi: 10.2174/1871527314666150116110212
