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In both patient cohorts, the change in eGFR after 5 years was significantly associated with age and height at baseline

Research protocols typically employ intermittent dosing strategies (once weekly or 3-day cycles) designed to prevent excessive apoptosis while enabling effective senescent cell elimination, with doses ranging from 5-10 mg/kg body weight in animal studies

They also play significant roles in cell differentiation, cell cycle, apoptosis, metastasis, angiogenesis, invasion, and development of tumors (Negrini et al., 2007)