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doi: 10.1186/s12879-024-09455-1, 72 MosmannJ

The pattern across the timeline is that tolerability improves as effect accrues the roughest GI window is early, precisely when weight change is smallest, and by the time therapeutic doses are driving measurable change the gut has usually adapted to each step

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Weight loss through GLP-1 treatment can help, but for men with clinically confirmed hypogonadism, it may not be enough to restore testosterone to an optimal range on its own