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In conclusion, the present data revealed that the intraperitoneal administration of NPW improves gastric injury in rats via the inhibition of the pro-inflammatory cytokine production, oxidative stress and inflammation as well as the downregulation of COX-2 protein and NF-B gene expressions

A mismatch between the breakdown rate of compounds in phase I and phase II can cause oxidative stress in the cells
10.1038/s41423-022-00858-1 15 BernardoV

The research indicates that IL-17A may induce depression-like behaviors by activating signaling pathways such as NF-B and p38 MAPK, which mediate inflammatory responses in the brain [111,289
