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Ferroptosis contributes to the progression of these illnesses by compromising retinal ganglion cell functionality

Damone AL, Joham AE, Loxton D, Earnest A, Teede HJ, Moran LJ

Notably, there are bile acid ligand specificity differences between FXR and TGR5, which have been exploited to generate bile acid derivatives that selectively activate the individual receptors or serve as agonists for both

The primary endpoint was area under the cagrilintide plasma concentration curve from time zero extrapolated to infinity (AUC 0 ) from baseline (day 1) to day 36 (renal impairment study) or day 39 (hepatic impairment study)