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In general, miRNAs are either bound to Argonaute-2 proteins (AGO2) or encapsulated in extracellular vesicles such as exosomes, microvesicles, or apoptotic bodies [285], which protects them from enzymatic degradation and ensures their stability

Data availability Original data generated and analyzed during this study are included in this published article, the supplementary material, or are available from the corresponding authors on reasonable request

Hence, studies have been focusing on understanding of the intrinsic abnormalities in T cells that lead to B-cell dysfunction [5]

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