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Description
Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs

Since KEAP1 negatively keeps the basal protein levels of NRF2 through the KEAP1-Cul3-RBX1 E3-ubiquitin ligase complex (see chapter 3.2), somatic mutations of KEAP1 abolish this protein-protein interaction with NRF2 and lead to NRF2 activation, which is targetable in lung cancer therapy

The expression levels of miR-195 exhibited a decrease in BV-2 cells upon stimulation with LPS, suggesting the potential involvement of miR-195 in the modulation of microglial activation
doi: 10.3389/fphar.2023.1267924 60
