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W., Sidman, C

These findings demonstrated the reduction of extracellular tissue tension (Fig

Secreted mainly by dermal papilla cells, IGF-1 promotes hair follicle cell proliferation, vascularization, and transition into the anagen (growth) phase through PI3K/Akt and MAPK/ERK signaling pathways

Hypoxia tends to maintain the levels of Hypoxia Inducible Factor (HIF-1), which regulates numerous cellular processes, including angiogenesis and proliferation, and as a result, can cause delayed wound healing ( Extracellular matrix The Extracellular matrix is a key environmental component in healing diabetic wounds, as it acts as a dynamic scaffold for cells and facilitates tissue development and regeneration ( Figure 2 )