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Thus, as animals and humans age, intestinal permeability increases [64][65][66][67][62][69] and could contributes to age-related bone loss

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(2003) Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance

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