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[149] George Whipple, George Minot and William Murphy were awarded the Nobel Prize in 1934 for their work on the vitamin
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The research rationale for a selective NNMT inhibitor is to interrupt exactly that diversion, so the cell keeps more of its NAD+ pool and can run its mitochondrial machinery again

By selectively inhibiting NNMT, 5-Amino-1MQ preserves SAM and NAD+ precursors, creating a metabolic environment that favors fat oxidation over fat storage
