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Despite the identification of numerous NET-inducing stimuli, the core mechanisms governing NET formation have remained poorly defined

Based on its powerful anti-inflammatory and neuroprotective activities, minocycline, a tetracycline antibiotic that can cross the BBB, is a candidate for the treatment of depression and anxiety

Of those 28 studies, only 20 studies (71%) assessed study outcomes in both sexes, and only 7 (25%) reported statistical analysis related to sex differences (Supplementary Table S1), with many studies claiming an inability to properly assess sex differences, given small sample sizes

2016;30(S1)