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Methylation analysis revealed differential patterns among glutamine biosynthesis genes (glutamate synthase (Dde_1250), acetylglutamate kinase (Dde_2015), glutamine synthetase (Dde_0102), glutamine synthetase, type I (Dde_0104)), whereas cysteine biosynthesis genes (homocysteine S-methyltransferase (Dde_2328), cystathionine beta-lyase (Dde_0276)) were moderately methylated, with significant methylation variability in glycine hydroxymethyltransferase (Dde_2432, PM_CB = 0.77, PM_CuB = 0.59), involved in glycine synthesis (Supplementary File S9)

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Mechanism of Tau hyperphosphorylation involving lysosomal enzyme asparagine endopeptidase in a mouse model of brain ischemia