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Description
While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial
doi: 10.1007/s11255-018-1973-z
Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis
Kikuchi, H., Pino, M
