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Description
The anti-apoptotic effects of luteolin can be mediated via several mechanisms such as reducing the levels of caspase-3 and 9 and improving the B-cell lymphoma protein 2/Bcl-2-associated X protein (Bcl-2/Bax) ratio, as it was reported in in vitro models of AD [61] and PD [62], as well as in vivo models of AD [63, 64] and PD [65, 66]

Additional studies continue to explore its role in downstream anabolic signaling, circadian hormone patterns, and coordinated pituitary response mechanisms

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[59], where curcumin was used as an adjunct to pharmaceutical antidepressants and administered for the shortest treatment period of all the trials (5 weeks)