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In addition, these reactive metabolites can bind to proteins, lipids, or nucleic acids and inhibit the enzymes in the mitochondrial ETC, resulting in oxidative stress, mitochondrial dysfunction, and hepatotoxicity [310, 311]
Hydrogen peroxide as second messenger in lymphocyte activation
The latest EUGOGO guidelines recommend a 6-month selenium supplementation for patients with mild and active TED of recent onset, because it improves eye manifestations and prevents progression to more severe forms [90]
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