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Subgroup and sensitivity analyses In subgroup analysis, new AHM users (initiated after January 1, 2011, with no prior AHM use) showed a non-significant 13% reduction in dementia risk with Ang-II stimulating AHMs compared to Ang-II inhibiting AHMs (aOR: 0.87, 95% CI 0.631.19, p = 0.392)

Effects on aging-related biology, cognitive performance, energy metabolism, antioxidant defense, or tissue repair (depending on the compound) are mediated through specific receptor or enzymatic pathways

It has been demonstrated that the human intestinal microbiota undergoes maturation from birth to adulthood and is further altered with aging

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