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A sulfate deprivation favors APS reduction for promoting cysteine, methionine, and glutathione synthesis whereas the presence of reduced sulfur sources represses APS reduction in the favor of APS phosphorylation (Takahashi et al., 1997

doi: 10.1016/j.ajpath.2024.01.019 20 CatapanoACimminoFPetrellaLPizzellaADAngeloMAmbrosioKet al

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If ascorbic acid caused glutathione to dissociate from hematin, the spectrum of either hematin or heme should appear, but this was not the case
