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Description
Overexpression of dFOXO has been shown to protect DA neurons in Drosophila Pink1 -null mutants [161], while other studies have shown that dFOXO-induced apoptosis mediates DA neuron death in Drosophila DJ-1 loss-of-function mutants [162] and dLRRK mutants [163]
In addition, as for CPP-mediated nose-to-brain delivery, the systemic exposure of nasally administered drugs might also occur because nasal coadministration of peptides with CPPs is shown to transport the peptide drugs to both systemic and brain compartments
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Macrophage experiments were conducted by L.B.R.S., X.Q., and B.B., and L.B.R.S
