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For proper management identifying the cause of pigmentation is key

As immunometabolic adjuvants to widen therapeutic windows, IDO inhibitors may leverage not only immuno-oncology modalities but also conventional chemotherapy and/or radiotherapy

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase
doi: 10.1038/s41598-018-31517-z 63 HallS.SurovaY.hrfeltA.ZetterbergH.LindqvistD.HanssonO
