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By virtue of this influence, GSH production encounters inhibition, ushering in a cascade of cellular responses ( 4.1.3 Iron accumulation inducing ferroptosis Erastin can elevate TFR levels through ROS-induced autophagy and facilitate the degradation of FTH1, thus orchestrating the regulation of intracellular iron levels

Finally, the interactions of peroxynitrite with membrane lipids may lead to the formation of various nitrated lipids, with potential biological properties as mediators of signal transduction both under physiological and pathological conditions (50), and of several intermediates products, including isoprostanes and 4-hydroxynonenal that can further trigger secondary oxidative insults (311)

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This metabolic shift occurs without changes in total energy expenditure, suggesting improved efficiency rather than increased caloric burn