Pigmented Lesions of the Vulva
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Description
IGF-1R is also known to bind the Wnt-signaling associated transcription factor LEF-1 [123], and upregulate TCF-mediated transcriptional activity of -catenin [123, 125]
Remarkably, torin-1 completely rescued threonine deprivationassociated cell death (Fig 4C), which was confirmed by experiments to block mTOR enzymatic activity (sapanisertib and rapalink), whereas rapamycin had no effect (Fig S6D)
Cancer Sci (2022) 113:376675
doi: 10.1089/fpd.2010.0730 37 PankeyG
