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In both adults and children with -thalassemia, bone marrow transplantation from an UD selected on the basis of high-resolution typing yields success rates similar to those obtained with a MSD [99], [100], but with more severe GVHD

While TB-500 has a favorable safety profile, cycling provides potential benefits including maintained receptor sensitivity, cost management, and reduced total exposure

Leukocytosis, thrombocytosis, eosinophilia, anemia, macrocytosis, or an abnormal blood smear all raise the priority of a hematologic cause
