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These results suggested that smaller particles are not necessarily better, and that there is an optimum size of nanoparticles to use for their delivery into the brain assisted by FUS-induced BBB opening

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However, it is essential to note that sustained elevation in plasma glucose concentrations due to reduced pancreatic insulin release from chronic melatonin treatment, especially when extending beyond the sleeping period [140], may compromise melatonins potential to ameliorate AD pathology [141, 142]