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Description
Glucocorticoid receptor activation inhibits mitogen-activated protein kinases (MAPK) via direct negative interaction on a protein-protein level or inhibition of MAPK phosphorylation

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Causes of CD, include Alzheimers disease, degenerative diseases, vascular dementia, certain types of drug abuse, depression, anxiety, disturbed sleep, hormones, metabolic disorders, diabetes mellitus, alcohol abuse, Lyme disease, hippocampal sclerosis, subdual and epidural hematomas, vitamin B12 deficiency, seizures, HIV-associated neurocognitive disorder, and Hashimotos encephalopathy

The equine neutrophilic proteinase inhibitors share their target specificity with eNAP-2, but in contrast they were stable at temperatures up to 100C and the inhibitory activity remained constant at a broad pH-range
