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However, their effectiveness is highly dependent to patient breathing pattern and requires patient coordination between actuation of the device and the breath pattern

2-week Preliminary Toxicity Study by the Oral Route (Dietary Admixture) in Rats, in Laboratory Study Number: 39240 TSR

This release of ascorbate contributes to a homeostatic mechanism for maintaining extracellular rat brain ascorbate at 200-400 M [53,96]