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Description
In BCS research, rats studies used occluding the inferior vena cava cranially to the hepatic veins, but bypassing of the occlusion in the rat BCS along with pharmacotherapy treatment was not considered
R.CommanderC
The mechanistic difference translates directly to side-effect profiles: cagrilintide causes nausea and vomiting in 3040% of subjects during dose titration (similar to GLP-1 agonists), while tesofensine produces insomnia, dry mouth, and increased heart rate in 2035% due to its sympathomimetic effects
Regul Toxicol Pharmacol 153:105709
