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doi:10.1080/00365520410009401 [58] Fasano A
Halestrap AP, Woodfield KY, Connern CP (1997) Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
Given that efficacy is related to trough levels, more frequent dosing may be sensible in patients with augmented renal clearance (e.g., 1 gram IV q8hrs rather than 1.5 grams q12hrs)
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