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When ARA-290 binds to the IRR, it does two critical things: It shuts down inflammation: It tells the immune system to stop attacking the damaged area, switching the focus from "defense" to "reconstruction." It stimulates regeneration: It promotes the sprouting of small nerve fibers, which are often the first to die in conditions like Small Fiber Neuropathy (SFN)

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Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded