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These authors contributed equally: Fabian Geissel, Lukas Lang

Due to their unique properties, such as high surface-to-mass ratio, stability, and ability to interact with both hydrophilic and hydrophobic environments, NPs show great promise in treating NDs, as their ability to mimic cell membrane structures and encapsulate diverse pharmaceuticals, along with their potential for functionalization, enhances their usefulness in drug delivery and bio-sensing (22)

However, it is disappointing that IGF-1 has not been shown to play a very significant role in promoting tendon healing in clinical trials, which could reflect our poor understanding of the molecular mechanisms by which IGF-1 is involved in promoting tendon regenerative healing