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Importantly, AdoHcy is a critically endogenous inhibitor of cellular methyltransferases, HHcy is easy to form hypomethylating environment, which further impairs methylation reactions related to intimal homeostasis (105)
Seveljevic Jaran D, Cuzic S, Dominis Kramaric M, Glojnaric I, Ivetic V, Radosevic S, et al
These points to a gap between laboratory findings and real world clinical effectiveness, further complicating their use
In addition, our subjects were highly trained distance runners
