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The activation of the kidney injury marker 1 (Kim-1)/NF-B/Nrf2 signaling pathway by lignocaine has been shown to protect against sodium fluoride-induced hypertension and associated cardiovascular complications, leading to improved NO bioavailability [276]

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Glutathione is a tripeptide antioxidant produced primarily in the liver, serving as the cell's master detoxifier and free-radical scavenger
