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Description
Treatment with recombinant human IGF1 (rhIGF1) is available for those with IGF-I deficiency caused by either Laron syndrome or IGF1 mutations

10.1104/pp.106.086975 Plant Physiol

Journal of Cellular Physiology, 232(10), 27312740

As the cellular damage produced by spontaneous generation of OH is not sufficient to be detectable, we induced O2 production in PC12 cultured cells
