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From a systems perspective, anxiety disorders is characterized by abnormalities in neurotransmitter functions, neurotrophic signaling, the endocannabinoid system and HPA axis function and these alterations are further compounded by chronic inflammation and maladaptive immune responses (Cai et al., 2025)
Disruption of these processes impairs mitochondrial dynamics and calcium handling, directly contributing to post-ischemic neuronal death [96]
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[DOI] [PubMed] 34.Gebara E., Udry F., Sultan S., Toni N
