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For this reason, patients with a history of immunoglobulin (Ig) Emediated (allergic or anaphylactic) reaction to a sulfonamide antibiotic can receive nonantimicrobial sulfonamides such as celecoxib, chlorthiazide, furosemide and others without elevated risk of an IgE-mediated reaction compared with the general population

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Researchers studying LM22A-4 should note that it is most commonly delivered intranasally in animal models, bypassing the blood-brain barrier through the olfactory pathway