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The decrease in MMP can lead to the opening of pores thus increasing mitochondrial membrane permeability (121), and a large amount of H+ pumped into the mitochondrial matrix causes a disruption of proton concentration on both sides of the mitochondrial membrane to inhibit ATP synthesis and accelerate ATP hydrolysis

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, Kibira S, Matsuishi T, Tsuji A

Funded studies must have the potential to impact the lives of patients within the next five years

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