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Glutathione peroxidase 2 inhibits cyclooxygenase-2-Mediated migration and invasion of ht-29 adenocarcinoma cells but supports their growth as tumors in nude mice

The possible underlying mechanism is associated with enhanced hepatic lipid oxidation via an Adenosine Monophosphate- Activated Protein Kinase- Acetyl-CoA carboxylase (AMPKAcetyl-CoA carboxylase) pathway, which leads to a reduction in liver fatty acid synthase activity, an increase in glycogen storage, and a decrease in tumor necrosis factor expression [157]