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Trimethylamine N-oxide promotes apoE(-/-) mice atherosclerosis by inducing vascular endothelial cell pyroptosis via the SDHB/ROS pathway

Another justification for the absence of an ergogenic effect in sports with a high aerobic component is the fact that the increase in the body mass of the subjects after treatment with creatine would lead to a possible neutralization of the beneficial effects, with body mass being of great relevance in these sports for optimal efficiency [69]

Importantly, this study also showed that this results in muscle glycogen sparing during low-intensity exercise (consistent with an increase in fat oxidation) and lower lactate accumulation during high-intensity exercise

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