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FIGURE 4 Research on PD patients has shown abnormal expression of proteins involved in autophagy (Table 5) and Atg and ULK genes, which increased upstream regulators of autophagy and decreased downstream regulators, strengthening the link between the disease and this cellular mechanism (Miki et al., 2018)

[122] found that oral NAC supplementation reduced serum levels of C-reactive protein

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Comprehensive assessment for DSPN involves evaluating small and large fiber function through temperature/pinprick sensation and 128-Hz tuning fork vibration sensation, respectively, along with 10-g monofilament testing to identify feet at risk of ulceration and amputation [46]