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The HCV genome comprises approximately 9,600 nucleotides and consists of an open reading frame (ORF) that encodes a large viral polyprotein of approximately 3,000 amino acids

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Consistent with this finding, resistance mutants to the humimycins, lipopeptides with antibacterial activity against some Gram-positive pathogens including methicillin-resistant Staphylococcus aureus 22 , map mostly to the cytoplasmic side of MurJ below the putative lipid II headgroup binding site 23

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