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However, LDHA has also been shown to metabolize alpha-ketoglutarate (-KG) to the L-(S)-enantiomeric form of 2-HG (L-2-HG), with similar inhibitory effects on histone demethylation ( Figure 1 IDH-mutant gliomas tend to have a missense mutation at codon 132 of IDH1, most commonly R132H, or at codons R140 or R172 of IDH2, such as R140Q or R172K
In contrast, beneficial bacteria, such as Lactobacillus , Alistipes , Olsenella , and Bifidobacterium , exhibited a negative correlation
33 , 36 Recommendations for the treatment of adverse effects during acetylcysteine therapy have been proposed
