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Importantly, clinical studies typically have indiscriminately tested interventions and have rarely utilised biomarkers or clinical symptoms to identify treatment responders, so the clinical indications are in some cases based on the authors opinion regarding the rationalisation of different management options

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doi: 10.1080/0886022x.2020.1822868 109 ZhengY.TangZ.YouL.WuY.LiuJ.XueJ