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Patient safety remains the primary consideration when determining MIC B12 injection protocols

If the vitamin B12 is ingested in its protein bound form, then it must first undergo a proteolytic cleavage in the stomach or duodenum where it will bind to an R-binder and then enter into the duodenum for further cleavage.1,2,8 This proteolytic cleavage is mostly dependent on the functional activity of pepsin

However, an important limitation remains: Current evidence is primarily preclinical, with limited published human clinical data

Peak synergy occurred when 2 nM vincristine was combined with 7.8 nM DPI, with an associated ZIP score of 13.6 ( Figure 5B )