effect of common glutathione-reducing pollutants on th1 th2 Deficient Glutathione in the Pathophysiology Mycotoxin-Related Illness Glutathione: A Samsonian life-sustaining small

10.1002/adhm.202100639 146 VellaV.MalaguarneraR.LappanoR.MaggioliniM.BelfioreA

Expressing a thiol-containing sensor such as roGFP2-Orp1 under a high-level constitutive promoter might disturb ER redox homeostasis, causing reductive stress (Ugalde et al ., 2022 a ), resulting in secretion of proteins with reduced thiols

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16 The same principle has been used to demonstrate the clonal origin of the malignant transformation of acute leukemia 17 , 18 and chronic myelocytic leukemia, 19 and also the clonal nature of polycythemia vera, 20 primary thrombocythemia, 21 and paroxysmal nocturnal hemoglobinuria