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You should expect to notice results in a few weeks

[81] Previous reports have suggested that the RIDA method can detect higher concentrations of vitamin B 12 in foods compared to the microbiological assay method
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Researchers set out to find an adequate dose at that age, and it seems we need at least about 650 to 1,000 a day in most people, hence my 1,000-a-day recommendation after age 65

doi: 10.2174/1389450053174596