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TLR4 is implicated in cardiac inflammation and development of hypertrophy through multiple signaling pathways, including TLR4/MyD88/Calcium/calmodulin-dependent protein kinase II (CaMK II), TLR4/MyD88/NF-B, TLR4/MyD88/PI3K/protein kinase B (AKT) and TLR4/MyD88/MAPK (Zhang et al., 2023)
Studies with similar ideas have achieved good results
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