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In particular, during glucose starvation or severe energy crises such as mitochondrial dysfunction, AMPK has been shown to negatively regulate ULK1 activity, either by inhibiting ULK1-dependent autophagosome formation or by disrupting lysosomal acidification, thereby attenuating autophagy initiation
(PubMed) Brubacher D, Moser U, Jordan P
All the applied UA concentrations (200 M to 800 M), both normal and pathological, triggered significant increase in the GR and GS mRNA levels
doi: 10.1139/cjpp-2012-0367
